circRNA basic information
circBase ID: -
Name: hsa_circ_BRWD1
Synonym: circ-BRWD1
Host Gene: hsa-miR-1277
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: CHON-001 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAF6
Associated microRNA: hsa-miR-1277
Biological function: Silencing of circ-BRWD1 promoted cell viability and proliferation and repressed apoptosis, inflammation, and extracellular matrix (ECM) degradation in IL-1beta-stimulated CHON-001 cells.
Molecular mechanism: circ-BRWD1 could serve as the sponge for miR-1277 to positively regulate TRAF6 expression.
Survival: -
Supported No.:
 1
Description:

Exosomal circ-BRWD1 promoted IL-1beta-induced CHON-001 cell progression by regulating miR-1277/TRAF6 axis.
Other information
Title:

Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis.

Journal: Arthritis Res Ther
Published: 2021/6/5
PubMed ID: 34082824