circRNA basic information
circBase ID: hsa_circ_0021087
Name: hsa_circ_LMO1
Synonym: Circ_0021087
Host Gene: hsa-miR-184
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal gastric epithelial cells GES-1, GC cells AGS, NCI-N87
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-184
Biological function: Circ_0021087 overexpression repressed GC cell proliferation and epithelial-mesenchymal transition (EMT) in xenograft models in vivo and induced GC cell apoptosis, repressed GC cell proliferation, EMT, migration and invasion in vitro
Molecular mechanism: Circ_0021087 could elevate FOSB expression by adsorbing hsa-miR-184
Survival: -
Supported No.:
 3
Description:

circ_0021087 played a repressive influence on GC progression by elevating FOSB expression by adsorbing miR-184, offering a new mechanism for circ_0021087 to inhibit the progression of GC.
Other information
Title:

Circ_0021087 acts as a miR-184 sponge and represses gastric cancer progression by adsorbing miR-184 and elevating FOSB expression.

Journal: Eur J Clin Invest
Published: 2021/6/3
PubMed ID: 34076278