circRNA basic information
circBase ID: -
Name: hsa_circ_MYLK
Synonym: CircMYLK
Host Gene: hsa-miR-34a
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: bladder carcinoma cell lines (SW780, T24, J82, RT4), bladder epithelium cells (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND3
Associated microRNA: hsa-miR-34a
Biological function: CircMYLK downregulation inhibited bladder cancer cell migration and invasion, and promoted cancer cell apoptosis and cell cycle arrest
Molecular mechanism: through the hsa-miR-34a/CCND3 regulatory network
Survival: -
Supported No.:
 3
Description:

CircMYLK contributed to the malignant development of bladder cancer cells partly through the miR-34a/CCND3 regulatory network.
Other information
Title:

CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.

Journal: Drug Dev Res
Published: 2021/6/1
PubMed ID: 34056735