circRNA basic information
circBase ID: hsa_circ_0066147
Name: hsa_circ_SFMBT1
Synonym: -
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PC cell lines (SW1990, PANC-1, Capan-2, BxPC-3, CFPAC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F2
Associated microRNA: hsa-miR-326
Biological function: circ_0066147 knockdown inhibited PC cell proliferation, migration, invasion and enhanced apoptosis in vitro, as well as weakened tumor growth in vivo
Molecular mechanism: circ_0066147 directly targeted hsa-miR-326 and circ_0066147 modulated E2F2 expression by hsa-miR-326
Survival: -
Supported No.:
 1
Description:

circ_0066147 regulated PC malignant progression in part depending on the miR-326/E2F2 axis, illuminating circ_0066147 was a potential prognostic marker and therapeutic target for PC management.
Other information
Title:

Mechanisms of circular RNA circ_0066147 on pancreatic cancer progression.

Journal: Open Life Sci
Published: 2021/6/1
PubMed ID: 34056113