circRNA basic information
circBase ID: -
Name: hsa_circ_ADD2
Synonym: circADD2
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 9952
DO name: acute lymphoblastic leukemia
Disease details: acute lymphoblastic leukemia
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Jurkat, 6T-CEM (T-ALL lines), Nalm-6 (B-ALL lines), 293T cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: AKT2
Associated microRNA: hsa-miR-149-5p
Biological function: inhibited cell proliferation and promoted apoptosis
Molecular mechanism: circADD2 could directly sponge hsa-miR-149-5p, and the level of AKT2, a target gene of hsa-miR-149-5p, was downregulated by circADD2
Survival: -
Supported No.:
 1
Description:

Overexpression of circADD2 inhibited cell proliferation and promoted apoptosis both in vitro and in vivo. Briefly, circADD2 could directly sponge miR-149-5p, and the level of AKT2, a target gene of miR-149-5p, was downregulated by circADD2.
Other information
Title:

Mechanism of circADD2 as ceRNA in Childhood Acute Lymphoblastic Leukemia.

Journal: Front Cell Dev Biol
Published: 2021/6/1
PubMed ID: 34055775