circRNA basic information
circBase ID: -
Name: hsa_circ_TPGS2
Synonym: circ-TPGS2
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal mammary epithelial cell line (MCF-10A), BC cell lines (MCF-7, T47D, SK-BR-3, MDA-MB231, BT-20)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAF6/NF-kappaB
Associated microRNA: hsa-miR-7
Biological function: promoted cell migration
Molecular mechanism: circ-TPGS2 acted as a sponge of hsa-miR-7 and elevated TRAF6, leading to p65 phosphorylation and nuclear translocation, ultimately activating NF-kappaB signalling
Survival: -
Supported No.:
 1
Description:

Dysregulation of tumour microenvironment driven by circ-TPGS2/miR-7/TRAF6/NF-kappaB axis facilitates breast cancer cell motility.
Other information
Title:

Dysregulation of tumour microenvironment driven by circ-TPGS2/miR-7/TRAF6/NF-kappaB axis facilitates breast cancer cell motility.

Journal: Autoimmunity
Published: 2021/5/27
PubMed ID: 34036857