circRNA basic information
circBase ID: hsa_circ_0008305
Name: hsa_circ_PTK2
Synonym: circ-PTK2
Host Gene: hsa-miR-639
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SK-OV-3, OVCAR-3
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXC1
Associated microRNA: hsa-miR-639
Biological function: expression of circ-PTK2 was found to be positively correlated to cell migration and invasion
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

By regulating the level of circ-PTK2 with siRNA and an overexpression vector, expression of circ-PTK2 was found to be positively correlated to cell migration and invasion. Overexpression of circ-PTK2 enhanced tumor formation and was correlated to expression of EMT pathway markers. Prediction of the target of circ-PTK2 was validated with dual luciferase assay and identified miR-639 and FOXC1 as the valid target of circ-PTK2 and miR-639, respectively.
Other information
Title:

circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade.

Journal: Cancer Cell Int
Published: 2021/5/27
PubMed ID: 34034740