circRNA basic information
circBase ID: hsa_circ_0027599
Name: -
Synonym: Circ_0027599
Host Gene: hsa-miR-21-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: GC cells (AGS, HGC-27), human normal gastric mucosal epithelial cells (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: RUNX1
Associated microRNA: hsa-miR-21-5p
Biological function: Circ_0027599 or RUNX1 overexpression inhibited GC cell viability, colony formation, migration, invasion and cell cycle process in vitro
Molecular mechanism: circ_0027599 positively regulated RUNX1 expression via functioning as the sponge for hsa-miR-21-5p
Survival: -
Supported No.:
 2
Description:

circ_0027599 overexpression repressed tumour growth in vivo. CONCLUSION: Circ_0027599 overexpression repressed GC progression via modulation of miR-21-5p/RUNX1 axis, which might illumine a novel therapeutic target for GC.
Other information
Title:

Circ_0027599 elevates RUNX1 expression via sponging miR-21-5p on gastric cancer progression.

Journal: Eur J Clin Invest
Published: 2021/5/26
PubMed ID: 34032284