circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_102229
Host Gene: hsa-miR-152-3p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human TNBC cell lines (SUM149PT, SUM159PT, MDA_MB_231, MDA_MB_468), parallel cell line (MCF10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PFTK1
Associated microRNA: hsa-miR-152-3p
Biological function: hsa_circ_102229 could promote the migration, proliferation and invasion, whereas it inhibited the apoptosis of TNBC cells
Molecular mechanism: regulate the expression of PFTK1 by targeting hsa-miR-152-3p
Survival: poor
Supported No.:
 1
Description:

Hsa_circ_102229 might serve as a competing endogenous RNA (ceRNA) to modulate PFTK1 expression via regulating miR-152-3p to affect the functions of TNBC cells.
Other information
Title:

Hsa_circRNA_102229 facilitates the progression of triple-negative breast cancer via regulating the miR-152-3p/PFTK1 pathway.

Journal: J Gene Med
Published: 2021/5/26
PubMed ID: 34031947