circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-558
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human metastatic bladder cancer cell line (T24T), human invasive bladder cancer cell line (UMUC3), human immortalized uroepithelium cell line (SV-HUC-1), endothelial cell line (HUVEC), SV-HUC-1 cells, HUVEC cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-558
Biological function: inhibits migration, invasion, and angiogenesis of bladder cancer cells
Molecular mechanism: sponge hsa-miR-558 to suppress the expression of heparanase (HPSE)
Survival: -
Supported No.:
 4
Description:

Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppresses bladder cancer growth and metastasis in vivo.
Other information
Title:

CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.

Journal: EMBO Rep
Published: 2017/8/11
PubMed ID: 28794202