circRNA basic information
circBase ID: hsa_circ_0000520
Name: -
Synonym: -
Host Gene: hsa-miR-556-5p
 
 
 
Disease basic information
DO ID:
 4481
DO name: allergic rhinitis
Disease details: allergic rhinitis
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NLRP3
Associated microRNA: hsa-miR-556-5p
Biological function: knock-down of hsa_circ_0000520 inactivated NLRP3-mediated epithelium pyroptosis through miR-556-5p in a ceRNA-dependent manner.
Molecular mechanism: both hsa_circ_0000520 ablation and miR-556-5p overexpression suppressed NLRP3-mediated cell pyroptosis to attenuate AR in mice models.
Survival: -
Supported No.:
 1
Description:

Taken together, we evidenced that targeting the hsa_circ_0000520/miR-556-5p/NLRP3 signaling pathway was a novel AQ1strategy to ameliorate AR progression; however, future clinical data are still required to validate our preliminary results.
Other information
Title:

Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models.

Journal: Inflamm Res
Published: 2021/5/25
PubMed ID: 34028600