circRNA basic information
circBase ID: hsa_circ_0010235
Name: hsa_circ_ALDH4A1
Synonym: -
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LUAD cell line (A-549), LULC cell lines (NCI-H2342, NCI-H1299), LUAD cell line (HCC827), human bronchial epithelioid cells (16HBE)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: KIF2A
Associated microRNA: hsa-miR-338-3p
Biological function: exhaustion of circ_0010235 induced apoptosis rate of NSCLC cells and curbed cell viability, EdU incorporation, migration rate and invasion rate
Molecular mechanism: interfering circ_0010235 delayed tumour growth of NSCLC cells by promoting hsa-miR-338-3p and E-cadherin expression, and depressing KIF2A, ki-67 and N-cadherin expression
Survival: -
Supported No.:
 4
Description:

Circ_0010235 was an upregulated circRNA in NSCLC patients and cells.Interfering circ_0010235 restrained NSCLC cell proliferation and metastasis in vitro and in vivo.miR-338-3p per se suppressed NSCLC in vitro and its downregulation diminished the tumour-suppressive role of circ_0010235 blockage in NSCLC cells.miR-338-3p could downstream target KIF2A and be sponged by circ_0010235.
Other information
Title:

Circular RNA circ_0010235 sponges miR-338-3p to play oncogenic role in proliferation, migration and invasion of non-small-cell lung cancer cells through modulating KIF2A.

Journal: Ann Med
Published: 2021/5/25
PubMed ID: 34024242