circRNA basic information
circBase ID: -
Name: hsa_circ_EPB41L2
Synonym: circEPB41L2
Host Gene: hsa-miR-21-5p, hsa-miR-942-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal colorectal mucous membrane cell line (FHC), colorectal cancer cells (SW620, SW480, HCT116, HT29)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN/AKT signalling pathway
Associated microRNA: hsa-miR-21-5p, hsa-miR-942-5p
Biological function: Overexpressed circEPB41L2 inhibited colorectal cancer cell proliferation, migration, invasion and promoted apoptosis, as well as suppressed the activity of PTEN/AKT signalling pathway
Molecular mechanism: sponge hsa-miR-21-5p or hsa-miR-942-5p
Survival: -
Supported No.:
 1
Description:

Overexpressed circEPB41L2 inhibited colorectal cancer cell proliferation, migration, invasion and promoted apoptosis, as well as suppressed the activity of PTEN/AKT signalling pathway. CircEPB41L2 could sponge miR-21-5p or miR-942-5p. MiR-21-5p or miR-942-5p could reverse the inhibition effect of circEPB41L2 on colorectal cancer progression and PTEN/AKT signalling pathway.
Other information
Title:

Exosomal circEPB41L2 serves as a sponge for miR-21-5p and miR-942-5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway.

Journal: Eur J Clin Invest
Published: 2021/5/23
PubMed ID: 34022068