circRNA basic information
circBase ID: hsa_circ_0001955
Name: -
Synonym: Circ_0001955
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HCC cell lines (SNU-387, Huh7), human liver epithelial cell line (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD4
Associated microRNA: hsa-miR-646
Biological function: Circ_0001955 knockdown inhibited the proliferation, metastasis, angiogenesis, and enhanced the apoptosis of HCC cells
Molecular mechanism: promoted FZD4 expression by sponging hsa-miR-646
Survival: -
Supported No.:
 5
Description:

circ_0001955 might play a positive role in HCC progression via regulating the miR-646/FZD4 axis, indicating that circ_0001955 might be a potential therapeutic target for HCC.
Other information
Title:

Circ_0001955 Acts as a miR-646 Sponge to Promote the Proliferation, Metastasis and Angiogenesis of Hepatocellular Carcinoma.

Journal: Dig Dis Sci
Published: 2021/5/23
PubMed ID: 34021822