circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK2
Synonym: -
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
 231
DO name: motor neuron disease
Disease details: neuroinflammatory disorders
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human astrocytoma cell line (A172)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1)
Associated microRNA: hsa-miR-124
Biological function: -
Molecular mechanism: targeting MIR124-2HG
Survival: -
Supported No.:
 1
Description:

the circular RNA HIPK2 (circHIPK2) functions as an endogenous microRNA-124 (MIR124-2HG) sponge to sequester MIR124-2HG and inhibit its activity, resulting in increased sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1) expression.
Other information
Title:

Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.

Journal: Autophagy
Published: 2017/8/9
PubMed ID: 28786753