circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: CircITCH
Host Gene: hsa-miR-17-5p
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NP cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: hsa-miR-17-5p
Biological function: CircITCH promoted apoptosis and decreased proliferation of NP cells
Molecular mechanism: activate Wnt/beta-catenin pathway by targeting hsa-miR-17-5p/SOX4 signaling
Survival: -
Supported No.:
 1
Description:

circITCH promotes ECM degradation in IDD by activating Wnt/beta-catenin through miR-17-5p/SOX4 signaling.
Other information
Title:

Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt/beta-catenin signaling in intervertebral disc degeneration.

Journal: Aging (Albany NY)
Published: 2021/5/21
PubMed ID: 34015763