circRNA basic information
circBase ID: hsa_circ_0010220
Name: hsa_circ_ARHGEF10L
Synonym: circ_0010220
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: osteosarcoma cell lines (HOS, U2OS), normal osteoblast cell line cells (hFOB 1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STX6
Associated microRNA: hsa-miR-198
Biological function: circ_0010220
Molecular mechanism: upregulated the expression of STX6 by sponging hsa-miR-198
Survival: poor
Supported No.:
 3
Description:

Circ_0010220 contributes to osteosarcoma progression through mediating miR-198/STX6 axis, which might be a novel therapeutic target for osteosarcoma therapy.
Other information
Title:

Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression.

Journal: J Bone Oncol
Published: 2021/5/18
PubMed ID: 33996428