circRNA basic information
circBase ID: -
Name: hsa_circ_GRHPR
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: immortalised human bronchial epithelial cells (BEAS_2B cells), human NSCLC cell lines (A549, H1975, H1299, PC_9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FHL3
Associated microRNA: -
Biological function: promotes NSCLC proliferation and invasion
Molecular mechanism: increased FHL3 expression in the nucleus of NSCLC cells by decreasing PCBP2 expression therein
Survival: -
Supported No.:
 1
Description:

four-and-a-half LIM-only protein 3 (FHL3) is a tumour-stimulating factor in NSCLC that interacts with and is influenced by PCBP2. Circ_GRHPR increased FHL3 expression in the nucleus of NSCLC cells by decreasing PCBP2 expression therein and promoting the proliferation and invasion of NSCLC cells.
Other information
Title:

The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA-binding protein PCBP2.

Journal: Clin Exp Pharmacol Physiol
Published: 2021/5/15
PubMed ID: 33987874