circRNA basic information
circBase ID: -
Name: hsa_circ_FADS2
Synonym: circFADS2
Host Gene: hsa-miR-15a-5p
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: sepsis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: lung cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-15a-5p
Biological function: Cell apoptosis analysis showed that circFADS2 overexpression reduced miR-15a-5p overexpression-induced apoptosis of LPS-treated lung cells.
Molecular mechanism: circFADS2 overexpression decreased the level of mature miR-15a-5p, but not miR-15a-5p precursor. LPS treatment decreased miR-15a-5p expression and increased circFADS2 level.
Survival: -
Supported No.:
 2
Description:

CircFADS2 is upregulated in sepsis to suppress LPS-induced lung cell apoptosis by inhibiting miR-15a-5p maturation.
Other information
Title:

Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p.

Journal: BMC Immunol
Published: 2021/5/14
PubMed ID: 33980140