circRNA basic information
circBase ID: hsa_circ_0072083
Name: hsa_circ_ZFR
Synonym: -
Host Gene: hsa-miR-1252-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: glioma cell lines (U251, U87), 293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NANOG and ALKBH5
Associated microRNA: hsa-miR-1252-5p
Biological function: circ_0072083 knockdown restrained the resistance of resistant cells via decreasing IC50 of TMZ, proliferation, migration, invasion and xenograft tumor growth and increasing apoptosis.
Molecular mechanism: circ_0072083 silence reduced NANOG expression via blocking ALKBH5-mediated demethylation. circ_0072083 could regulate NANOG and ALKBH5 via targeting hsa-miR-1252-5p to control TMZ resistance
Survival: -
Supported No.:
 1
Description:

Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR-1252-5p-mediated degradation and demethylation in glioma.
Other information
Title:

Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma.

Journal: J Exp Clin Cancer Res
Published: 2021/5/13
PubMed ID: 33975615