circRNA basic information
circBase ID: hsa_circ_0128846
Name: hsa_circ_ZFR
Synonym: -
Host Gene: hsa-miR-127-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OA chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NAMPT
Associated microRNA: hsa-miR-127-5p
Biological function: Knockdown of circ_0128846 increased cell viability and inhibited apoptosis, inflammation and ECM degradation in OA chondrocytes
Molecular mechanism: positively regulated NAMPT expression by sponging hsa-miR-127-5p
Survival: -
Supported No.:
 2
Description:

Circ_0128846 knockdown might inhibit the progression of OA by upregulating miR-127-5p and downregulating NAMPT.
Other information
Title:

Circular RNA circ_0128846 promotes the progression of osteoarthritis by regulating miR-127-5p/NAMPT axis.

Journal: J Orthop Surg Res
Published: 2021/5/13
PubMed ID: 33975612