circRNA basic information
circBase ID: -
Name: hsa_circ_CNST
Synonym: circ-CNST
Host Gene: hsa-miR-578
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human OS tissues, 143B, U2OS cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LDHA/PDK1
Associated microRNA: hsa-miR-578
Biological function: blocking circ-CNST and restoring miR-578 enhanced apoptosis rate and suppressed cell proliferation, colony formation, migration, and invasion in 143B and U2OS cells, accompanied with decreased glucose consumption, lactate production, and adenosine triphosphate (ATP)/adenosine diphosphate (ADP) ratio
Molecular mechanism: hsa-miR-578 was targeted by circ-CNST, and hsa-miR-578 could target LDHA/PDK1
Survival: poor
Supported No.:
 2
Description:

Circ-CNST knockdown could antagonize malignant behaviors and glycolysis of OS cells by regulating miR-578-LDHA/PDK1 axes.
Other information
Title:

Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks.

Journal: J Orthop Surg Res
Published: 2021/5/9
PubMed ID: 33962616