circRNA basic information
circBase ID: -
Name: hsa_circ_NRIP1
Synonym: -
Host Gene: hsa-miR-595
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: KYSE30, KYSE450 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SEMA4D
Associated microRNA: hsa-miR-595
Biological function: Knockdown of circ_NRIP1 could enhance apoptosis rate and E-cadherin expression, but suppress colony formation, cell viability, migration, invasion, and snail expression in KYSE30 and KYSE450 cells, as well as retarded tumor growth in mice
Molecular mechanism: circ_NRIP1 was a sponge for hsa-miR-595, and SEMA4D was a target of hsa-miR-595
Survival: -
Supported No.:
 2
Description:

circ_NRIP1 functioned as an oncogene in ESCC, and modulated ESCC cell growth, migration and invasion both in vitro and in vivo via targeting miR-595/SEMA4D axis and inhibiting PI3K/AKT signaling pathway.
Other information
Title:

circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway.

Journal: Cancer Cell Int
Published: 2021/5/8
PubMed ID: 33957921