circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_102481
Host Gene: hsa-miR-30a-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: gefitinib sensitive cell lines (PC9), gefitinib resistant cell lines (PC9/GR), erlotinib sensitive cell lines (HCC827), erlotinib resistant cell lines (HCC827/ER)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: ROR1
Associated microRNA: hsa-miR-30a-5p
Biological function: circRNA_102481 overexpression could promote EGFR-TKIs sensitive cell proliferation and inhibit cell apoptosis
Molecular mechanism: served as a hsa-miR-30a-5p sponge to regulate ROR1 expression
Survival: poor
Supported No.:
 1
Description:

tumor-derived exosomal circRNA_ 102481 could contribute to EGFR-TKIs resistance via the microRNA-30a-5p/ROR1 axis in NSCLC.
Other information
Title:

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer.

Journal: Aging (Albany NY)
Published: 2021/5/7
PubMed ID: 33952725