circRNA basic information
circBase ID: hsa_circ_0008305
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: hsa-miR-181c-5p
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: sepsis
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-181c-5p
Biological function: Overexpression of HMGB1 enhanced the effect of LPS, while silencing HMGB1 partially counteracted the effect of LPS.
Molecular mechanism: _iR-181c-5p was a target of circPTK2 and bound to HMGB1.
Survival: -
Supported No.:
 1
Description:

Our research reveals that circPTK2 regulates microglia activation and hippocampal neuronal apoptosis induced by sepsis via miR-181c-5p-HMGB1 signaling.
Other information
Title:

CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis.

Journal: Mol Med
Published: 2021/5/7
PubMed ID: 33952191