circRNA basic information
circBase ID: hsa_circ_0017956
Name: hsa_circ_MLLT10
Synonym: -
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (A549, H1299), human bronchial epithelial cell line (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ITGB8
Associated microRNA: hsa-miR-515-5p
Biological function: Circ_0017956 knockdown caused inhibitory effects on the proliferative and metastasizing capacities of NSCLC cells
Molecular mechanism: sponging hsa-miR-515-5p and upregulating ITGB8 level
Survival: -
Supported No.:
 2
Description:

Circ_0017956 could promote NSCLC carcinogenesis at least partly through sponging miR-515-5p and upregulating ITGB8 level, providing a novel theoretical basis for NSCLC treatment.
Other information
Title:

Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis.

Journal: Cell Cycle
Published: 2021/5/5
PubMed ID: 33945401