circRNA basic information
circBase ID: hsa_circ_0091579
Name: hsa_circ_GPC3
Synonym: -
Host Gene: hsa-miR-624
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal liver cells (MIHA), HCC cell lines (Hep3B, MHCC97-H, Huh7), 293T cells, human immortal liver cells (C3A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: H3F3B
Associated microRNA: hsa-miR-624
Biological function: Circ_0091579 inhibition decreased xenograft tumor growth in vivo and repressed Warburg effect, migration, invasion, and induced apoptosis of HCC cells in vitro.
Molecular mechanism: Circ_0091579 acted as a hsa-miR-624 sponge and regulated H3F3B expression by adsorbing hsa-miR-624
Survival: -
Supported No.:
 6
Description:

Circ_0091579 accelerated Warburg effect and tumor growth via upregulating H3F3B via adsorbing miR-624 in HCC, providing evidence to support the involvement of circ_0091579 in the progression of HCC.
Other information
Title:

Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis.

Journal: Clin Transl Oncol
Published: 2021/5/3
PubMed ID: 33934291