circRNA basic information
circBase ID: hsa_circ_0038467
Name: hsa_circ_UQCRC2
Synonym: circ-UQCRC2
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 552
DO name: pneumonia
Disease details: pneumonia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MRC-5 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDCD4
Associated microRNA: hsa-miR-326
Biological function: The silencing of circ-UQCRC2 attenuated LPS-induced MRC-5 cell injury.
Molecular mechanism: circ-UQCRC2 directly targeted miR-326, and circ-UQCRC2 regulated PDCD4 expression through miR-326.
Survival: -
Supported No.:
 4
Description:

Our findings demonstrated a novel regulatory network, the miR-326/PDCD4/NF-¦ĘB pathway, for the function of circ-UQCRC2 in LPS-induced cell injury in MRC-5 cells.
Other information
Title:

Knockdown of circ-UQCRC2 ameliorated lipopolysaccharide-induced injury in MRC-5 cells by the miR-326/PDCD4/NF-kappaB pathway.

Journal: Int Immunopharmacol
Published: 2021/4/26
PubMed ID: 33895481