circRNA basic information
circBase ID: hsa_circ_0110102
Name: -
Synonym: -
Host Gene: hsa-miR-580-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HepG2, MHCC-97H, Huh-7, Hep-3B, SMCC-7721
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PPARalpha/CCL2
Associated microRNA: hsa-miR-580-5p
Biological function: Knockdown hsa_circ_0110102 significantly promoted cell proliferation, migration, and invasion
Molecular mechanism: via hsa-miR-580-5p/PPARalpha/CCL2 pathway
Survival: -
Supported No.:
 1
Description:

hsa_circ_0110102 acted as a sponge for miR-580-5p and inhibited CCL2 secretion into tumor microenvironment by decrease the expression of PPARalpha in HCC cells, then inhibited the pro-inflammatory cytokine release from macrophages by regulating the COX-2/PGE2 pathway.
Other information
Title:

CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARalpha/CCL2 pathway.

Journal: Aging (Albany NY)
Published: 2021/4/24
PubMed ID: 33891564