circRNA basic information
circBase ID: -
Name: hsa_circ_TRAF3
Synonym: -
Host Gene: hsa-miR-203a-3p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: C666-1, SUNE1, 5-8_F, HNE1, HNE2
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT3
Associated microRNA: hsa-miR-203a-3p
Biological function: Knockdown of circTRAF3 could inhibit NPC cell proliferation and cell invasion, and induce apoptosis
Molecular mechanism: circTRAF3 eliminated the inhibitory effect of hsa-miR-203a-3p on AKT3 by adsorbing hsa-miR-203a-3p
Survival: poor
Supported No.:
 1
Description:

circTRAF3, which acts as an oncogene in NPC and targets miR-203a-3p/AKT3 pathway. The circTRAF3/miR-203a-3p/AKT3 pathway may be a potential therapeutic target for metastatic NPC.
Other information
Title:

CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.

Journal: Pathol Res Pract
Published: 2021/4/23
PubMed ID: 33887546