circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: -
Host Gene: hsa-miR-30e-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549, H1299, NCI-H1975
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: USP22
Associated microRNA: hsa-miR-30e-5p
Biological function: circFAT1(e2) gene knockdown could significantly inhibit the proliferation, migration, and invasion of NSCLC cells
Molecular mechanism: circFAT1(e2) acted as a ceRNA to spongy hsa-miR-30e-5p, which led to the increase in USP22 and promoted cell growth
Survival: -
Supported No.:
 1
Description:

circFAT1(e2) gene knockdown could significantly inhibit the proliferation, migration, and invasion of NSCLC cells. Loss of function testing found that circFAT1(e2) functioned as an oncogene in NSCLC cells. In addition, circFAT1(e2) acted as a ceRNA to spongy miR-30e-5p, which led to the increase in USP22 and promoted cell growth.

Other information
Title:

circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22.

Journal: Biomed Res Int
Published: 2021/4/23
PubMed ID: 33884267