circRNA basic information
circBase ID: -
Name: hsa_circ_LRIG3
Synonym: -
Host Gene: hsa-miR-449a
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Huh7, Hep3B
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RNF38
Associated microRNA: hsa-miR-449a
Biological function: Knockdown of circ_LRIG3 suppressed proliferation, migration and invasion and facilitated cell apoptosis
Molecular mechanism: inhibit the Smad2/3 pathway
Survival: -
Supported No.:
 3
Description:

circ_LRIG3 facilitated HCC progression by modulation of miR-449a/LRIG3 axis, which might provide a novel method for HCC therapy.
Other information
Title:

circ_LRIG3 contributes to the progression of hepatocellular carcinoma by elevating RNF38 via sponging miR-449a.

Journal: Gen Physiol Biophys
Published: 2021/4/22
PubMed ID: 33880997