circRNA basic information
circBase ID: -
Name: hsa_circ_E2F3
Synonym: -
Host Gene: hsa-miR-204-5p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Y79, SO-RB50, WERI-RB-1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1
Associated microRNA: hsa-miR-204-5p
Biological function: Silencing of circ-E2F3 inhibited the proliferation, migration, invasion, and induced the apoptosis of RB cells in vitro, as well as reduced RB tumor growth in vivo
Molecular mechanism: positively regulated ROCK1 expression by sponging hsa-miR-204-5p
Survival: -
Supported No.:
 1
Description:

Circ-E2F3 functioned as a tumor promoter in RB through the miR-204-5p/ROCK1 axis.
Other information
Title:

Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression.

Journal: Exp Mol Pathol
Published: 2021/4/13
PubMed ID: 33844975