circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_100395
Host Gene: hsa-miR-142-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HGC-27 MKN45, NCI-N87, SNU-5, AGS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PI3K/AKT signaling pathway
Associated microRNA: hsa-miR-142-3p
Biological function: suppressed cell proliferation, increased the apoptosis rate and suppressed cell invasion and migration
Molecular mechanism: by targeting the PI3K/AKT axis
Survival: better
Supported No.:
 1
Description:

These findings also showed that miRNA-142-3p rescued the antitumor effects induced by circRNA_100395-overexpression. cirRNA_100395-overexpression had antitumor effects via regulating the miR-142-3p signaling pathway, which might be a promising treatment target for GC.
Other information
Title:

Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis.

Journal: Oncol Lett
Published: 2021/4/13
PubMed ID: 33841580