circRNA basic information
circBase ID: -
Name: hsa_circ_ANKRD11
Synonym: circANKRD11
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 3083
DO name: chronic obstructive pulmonary disease
Disease details: Chronic obstructive pulmonary disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HPMECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BRD4
Associated microRNA: hsa-miR-145-5p
Biological function: CircANKRD11 silencing ameliorated CSE-induced cell apoptosis, inflammation, and oxidative stress.
Molecular mechanism: CircANKRD11 acted as a sponge of miR-145-5p, and regulated CSE-induced cell injury via sponging miR-145-5p.
Survival: -
Supported No.:
 1
Description:

CircANKRD11 absence protected HPMECs from CSE-induced injury by regulating BRD4 through associating with miR-145-5p, which demonstrated that circANKRD11 had the potential to act as a diagnosis biomarker for smoker-caused COPD.
Other information
Title:

CircANKRD11 Knockdown Protects HPMECs from Cigarette Smoke Extract-Induced Injury by Regulating miR-145-5p/BRD4 Axis.

Journal: Int J Chron Obstruct Pulmon Dis
Published: 2021/4/10
PubMed ID: 33833509