circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: -
Host Gene: hsa-miR-409-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SiHa, SW756, CaScki, C-33A
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK8
Associated microRNA: hsa-miR-409-3p
Biological function: CircFAT1 knockdown resulted in the suppression of proliferation, migration and invasion, and promotion of apoptosis in CC cells via the inactivation of ERK1/2 and p38 MAPK pathway
Molecular mechanism: directly sponged hsa-miR-409-3p and then relieved the repressive effect of hsa-miR-409-3p on its target CDK8
Survival: -
Supported No.:
 1
Description:

CircFAT1 promoted CC progression via activating ERK1/2 and p38 MAPK pathway through the miR-409-3p/CDK8 axis, suggesting a promising prognostic biomarker and therapeutic target for CC.
Other information
Title:

CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR-409-3p/CDK8 axis.

Journal: Drug Dev Res
Published: 2021/4/6
PubMed ID: 33818788