circRNA basic information
circBase ID: -
Name: hsa_circ_GRN
Synonym: -
Host Gene: hsa-miR-214-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HVSMCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXO1
Associated microRNA: hsa-miR-214-3p
Biological function: Promotes the Proliferation, Migration, and Inflammation
Molecular mechanism: through hsa-miR-214-3p/FOXO1 axis
Survival: -
Supported No.:
 3
Description:

circ_GRN promoted the proliferation, migration, and inflammation of HVSMCs through miR-214-3p/FOXO1 axis in ox-LDL-induced AS model in vitro, suggesting the potential involvement in an AS process, which provided a potential candidate for future clinic intervention in AS.
Other information
Title:

Circ_GRN Promotes the Proliferation, Migration, and Inflammation of Vascular Smooth Muscle Cells in Atherosclerosis Through miR-214-3p/FOXO1 Axis.

Journal: J Cardiovasc Pharmacol
Published: 2021/4/6
PubMed ID: 33818550