circRNA basic information
circBase ID: -
Name: hsa_circ_ABCC3
Synonym: -
Host Gene: hsa-miR-770-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: T98G, LN229, U138, SHG44, A172, U251
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX2
Associated microRNA: hsa-miR-770-5p
Biological function: CircABCC3 absence inhibited cell proliferation, migration, invasion, tube formation and the activation of PI3K/AKT pathway, whereas induced cell apoptosis in glioblastoma
Molecular mechanism: acted as a sponge for hsa-miR-770-5p, and hsa-miR-770-5p targeted SOX2
Survival: poor
Supported No.:
 1
Description:

CircABCC3 regulated glioblastoma development via miR-770-5p/SOX2 axis through PI3K/AKT pathway. This finding lays a theoretical foundation for studying circRNA-directed therapy for glioblastoma.
Other information
Title:

CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.

Journal: Brain Res
Published: 2021/4/4
PubMed ID: 33811842