circRNA basic information
circBase ID: hsa_circ_0009035
Name: hsa_circ_RACGAP1
Synonym: -
Host Gene: hsa-miR-889-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HeLa, Siha
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HOXB7
Associated microRNA: hsa-miR-889-3p
Biological function: the silencing of hsa_circ_0009035 inhibited CC cell proliferation, migration, invasion, and it enhanced apoptosis and radiosensitivity in vitro and weakened tumor growth in vivo.
Molecular mechanism: hsa_circ_0009035 directly targeted hsa-miR-889-3p by binding to hsa-miR-889-3p, and hsa_circ_0009035 modulated HOXB7 expression through hsa-miR-889-3p
Survival: -
Supported No.:
 2
Description:

hsa_circ_0009035 as an important regulator of CC progression and radioresistance at least in part through targeting the miR-889-3p/HOXB7 axis, highlighting its significance as a potential therapeutic target for CC treatment.
Other information
Title:

Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7.

Journal: Mol Cell Biol
Published: 2021/3/31
PubMed ID: 33782039