circRNA basic information
circBase ID: -
Name: hsa_circ_SKA3
Synonym: -
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 0050902
DO name: medulloblastoma
Disease details: medulloblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Daoy, D283 Med
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ID3
Associated microRNA: hsa-miR-326
Biological function: Depleted expression of circ-SKA3 inhibited MB cell proliferation, migration and invasion and induced apoptosis and cell cycle arrest, and circ-SKA3 knockdown inhibited MB growth in vivo
Molecular mechanism: circ-SKA3 directly targeted hsa-miR-326 that could bind to ID3, and circ-SKA3 decoyed hsa-miR-326 to increasing ID3 expression
Survival: -
Supported No.:
 4
Description:

circ-SKA3 functioned as an oncogene to promote the development of MB by increasing ID3 expression via decoying miR-326, hinting that circ-SKA3 might be a therapeutic target of MB.
Other information
Title:

Circ-SKA3 upregulates ID3 expression by decoying miR-326 to accelerate the development of medulloblastoma.

Journal: J Clin Neurosci
Published: 2021/3/30
PubMed ID: 33775353