circRNA basic information
circBase ID: -
Name: hsa_circ_KRT6C
Synonym: -
Host Gene: hsa-miR-16-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDL1
Associated microRNA: hsa-miR-16-5p
Biological function: The suppression of circ-KRT6C suppressed growth, migration, invasion, and immune escape while stimulating apoptosis in colorectal cancer cells
Molecular mechanism: increase programmed cell death receptor ligand 1 expression by functioning as a microRNA-16-5p sponge
Survival: poor
Supported No.:
 1
Description:

circ-keratin 6c could increase programmed cell death receptor ligand 1 expression by functioning as a microRNA-16-5p sponge, which promoted malignant progression and immune evasion of colorectal cancer.
Other information
Title:

circ-Keratin 6c Promotes Malignant Progression and Immune Evasion of Colorectal Cancer through microRNA-485-3p/Programmed Cell Death Receptor Ligand 1 Axis.

Journal: J Pharmacol Exp Ther
Published: 2021/3/28
PubMed ID: 33771844