circRNA basic information
circBase ID: -
Name: hsa_circ_RUNX1
Synonym: -
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SW480, SW620
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SLC38A1
Associated microRNA: hsa-miR-485-5p
Biological function: CircRUNX1 deficiency restrained CRC cell colony formation, migration, invasion and glutaminolysis and induced apoptosis in vitro as well as blocked tumour growth in vivo.
Molecular mechanism: CircRUNX1 directly sponged hsa-miR-485-5p, which negatively modulated SLC38A1 expression in CRC cells.
Survival: -
Supported No.:
 2
Description:

CircRUNX1 promoted CRC cell growth, metastasis and glutamine metabolism and repressed apoptosis by elevating SLC38A1 through sponging miR-485-5p, which might provide a novel target for CRC treatment.
Other information
Title:

CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR-485-5p/SLC38A1 axis.

Journal: Eur J Clin Invest
Published: 2021/3/27
PubMed ID: 33769559