circRNA basic information
circBase ID: hsa_circ_0074027
Name: -
Synonym: cirRNA_0074027
Host Gene: hsa-miR-525-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Caco-2, LoVo, SW480, HCT-116, HCT-8
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: p53
Associated microRNA: hsa-miR-525-3p
Biological function: Deletion of circRNA_0074027 could suppress cell proliferation and metastasis
Molecular mechanism: through up-regulating p53 expression and forbidding epithelial_mesenchymal transition signaling pathway
Survival: -
Supported No.:
 1
Description:

The addition of miRNA_525_3p inhibitors could reverse the anti_tumor effects induced by the deletion of circRNA_0074027. The downregulation of cirRNA_0074027 inhibited tumor progression via sponging miR_525_3p, which could be a promising treatment bio_marker for CRC.
Other information
Title:

Circular RNA_0074027 participates in cell proliferation, apoptosis and metastasis of colorectal cancer cells through regulation of miR_525_3p.

Journal: Mol Med Rep
Published: 2021/3/25
PubMed ID: 33760126