circRNA basic information
circBase ID: -
Name: hsa_circ_RSF1
Synonym: circRSF1
Host Gene: hsa-miR-135b-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: Atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: Human umbilical vein endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HDAC1
Associated microRNA: hsa-miR-135b-5p
Biological function: promotion of circRSF1 or inhibition of miR-135b-5p induced cell proliferation while inhibited apoptosis and inflammation of ox-LDL-treated HUVECs, which was reversed by upregulating miR-135b-5p or downregulating HDCA1 in ox-LDL-treated HUVECs.
Molecular mechanism: circRSF1 directly targeted miR-135b-5p and HDAC1 was a target mRNA of miR-135b-5p in HUVECs.
Survival: -
Supported No.:
 3
Description:

CircRSF1 regulated ox-LDL-induced vascular endothelial cell proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in AS, providing new perspectives and methods for the treatment and diagnosis of AS.
Other information
Title:

CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.

Journal: Biol Res
Published: 2021/3/25
PubMed ID: 33757583