circRNA basic information
circBase ID: -
Name: -
Synonym: circ1662
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCT116
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: -
Biological function: circ1662 promoted CRC cell invasion and migration by controlling EMT in vitro and in vivo
Molecular mechanism: circ1662 directly bound to YAP1 and accelerated its nuclear accumulation to regulate the SMAD3 pathway
Survival: -
Supported No.:
 1
Description:

METTL3-induced circ1662 promoted CRC cell invasion and migration by accelerating YAP1 nuclear transport. This result implies that circ1662 is a new prognostic and therapeutic marker for CRC metastasis.
Other information
Title:

N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.

Journal: Theranostics
Published: 2021/3/24
PubMed ID: 33754062