circRNA basic information
circBase ID: -
Name: hsa_circ_VRK1
Synonym: -
Host Gene: hsa-miR-221-3P
 
 
 
Disease basic information
DO ID:
 10591
DO name: pre-eclampsia
Disease details: preeclampsia
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PTEN/Akt
Associated microRNA: hsa-miR-221-3P
Biological function: circVRK1 knockdown significantly enhanced cell migration and invasion abilities, as well as epithelial-mesenchymal transition (EMT).
Molecular mechanism: circVRK1 and PTEN could function as the ceRNAs to hsa-miR-221-3p
Survival: -
Supported No.:
 1
Description:

circVRK1 suppresses trophoblast cell migration, invasion and EMT, by acting as a ceRNA to miR-221-3p to regulate PTEN, and further inhibit PI3K/Akt activation. The purpose of this paper is to open wide insights to investigate the onset of PE and provide new potential therapeutic targets in PE.
Other information
Title:

Circular RNA VRK1 facilitates pre-eclampsia progression via sponging miR-221-3P to regulate PTEN/Akt.

Journal: J Cell Mol Med
Published: 2021/3/20
PubMed ID: 33738906