circRNA basic information
circBase ID: -
Name: hsa_circ_FAM73A
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: AGS, HGC27, MKN45, MGC803, SGC7901, BGC823
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

Our work demonstrates the crucial role of circFAM73A in the CSC-like properties of GC and uncovers a positive feedback loop in circFAM73A regulation that leads to the progression of gastric cancer, which may provide new insights into circRNA-based diagnostic and therapeutic strategies.
Other information
Title:

CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated beta-catenin stabilization.

Journal: J Exp Clin Cancer Res
Published: 2021/3/19
PubMed ID: 33731207