circRNA basic information
circBase ID: -
Name: hsa_circ_PITX1
Synonym: -
Host Gene: hsa-miR-1248
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC827, H1650
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND2
Associated microRNA: hsa-miR-1248
Biological function: Circ-PITX1 was upregulated in NSCLC and its silencing could inhibit the proliferation, migration, invasion, cell cycle process, glycolysis, glutamine metabolism, and promote the apoptosis of NSCLC cells in vitro, as well as reduced tumor growth in vivo
Molecular mechanism: circ-PITX1 could act as a sponge of hsa-miR-1248, and hsa-miR-1248 could target CCND2
Survival: -
Supported No.:
 3
Description:

Circ-PITX1 served as a sponge of miR-1248 to promote NSCLC progression by upregulating CCND2.
Other information
Title:

Circ-PITX1 Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1248/CCND2 Axis.

Journal: Onco Targets Ther
Published: 2021/3/18
PubMed ID: 33727831