circRNA basic information
circBase ID: hsa_circ_0003420
Name: -
Synonym: circ_0003420
Host Gene: -
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: sepsis-induced liver damage
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

We demonstrate that circ_0003420 targets NPAS4 mRNA thereby mediating the cell damage and inflammation caused by LPS. This study provides a possible target for treatment of liver damage induced by sepsis.
Other information
Title:

Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4.

Journal: Immunopharmacol Immunotoxicol
Published: 2021/3/16
PubMed ID: 33719821