circRNA basic information
circBase ID: hsa_circ_0074027
Name: -
Synonym: circ_0074027
Host Gene: hsa-miR-2467-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A549, H1299, H358, H1581
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RHOA
Associated microRNA: hsa-miR-2467-3p
Biological function: Circ_0074027 knockdown or miR-2467-3p overexpression suppressed cell proliferation, migration and invasion and facilitated cell apoptosis of NSCLC cells.
Molecular mechanism: interacted with hsa-miR-2467-3p, and RHOA was a target of hsa-miR-2467-3p
Survival: -
Supported No.:
 2
Description:

circ_0074027 accelerated NSCLC progression by binding to miR-2467-3p to induce RHOA expression.
Other information
Title:

Circ_0074027 contributes to non-small cell lung cancer progression through positively modulating RHOA via sequestering miR-2467-3p.

Journal: J Bioenerg Biomembr
Published: 2021/3/10
PubMed ID: 33687619